pentobarbital will lower the level or outcome of colchicine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.pentobarbital boosts toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. CYP3A4 inducers may enhance the metabolism of ifosfamide to its active alkylating metabolit… Read More